Discovery and characterization of novel trans-spliced products of human polyoma JC virus late transcripts from PML patients.

ABSTRACT: Although the human neurotropic polyomavirus, JC virus (JCV), was isolated almost a half century ago, understanding the molecular mechanisms governing its biology remains highly elusive. JCV infects oligodendrocytes and astrocytes in the central nervous system (CNS) and causes a rare fatal brain disease known as progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals including AIDS. It has a small circular DNA genome (∼5 kb) and generates two primary transcripts from its early and late coding regions, producing several predicted alternatively spliced products mainly by cis-splicing. Here, we report the discovery and characterization of two novel open reading frames (ORF1 and ORF2) associated with JCV late transcripts, generated by an unusual splicing process called

SUBMITTER: Saribas AS 

PROVIDER: S-EPMC5805571 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature