Genetic variants in the platelet-derived growth factor subunit B gene associated with pancreatic cancer risk.

ABSTRACT: The platelet-derived growth factor (PDGF) signaling pathway plays important roles in development and progression of human cancers. In our study, we aimed to identify genetic variants of the PDGF pathway genes associated with pancreatic cancer (PC) risk in European populations using three published genome-wide association study datasets, which consisted of 9,381 cases and 7,719 controls. The expression quantitative trait loci (eQTL) analysis was also performed using data from the 1000 Genomes, TCGA and GTEx projects. As a result, we identified two potential susceptibility loci (rs5757573 and rs6001516) of PDGFB associated with PC risk [odds ratio (OR) = 1.10, 95% confidence interval (CI) = 1.05-1.16, and p = 4.70 × 10^-5 for the rs5757573 C allele and 1.21, 1.11-1.32, and 2.01 × 1

SUBMITTER: Duan B 

PROVIDER: S-EPMC5805574 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature