The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution.

ABSTRACT: The sea lamprey (Petromyzon marinus) serves as a comparative model for reconstructing vertebrate evolution. To enable more informed analyses, we developed a new assembly of the lamprey germline genome that integrates several complementary data sets. Analysis of this highly contiguous (chromosome-scale) assembly shows that both chromosomal and whole-genome duplications have played significant roles in the evolution of ancestral vertebrate and lamprey genomes, including chromosomes that carry the six lamprey HOX clusters. The assembly also contains several hundred genes that are reproducibly eliminated from somatic cells during early development in lamprey. Comparative analyses show that gnathostome (mouse) homologs of these genes are frequently marked by polycomb repressive complexes (PRCs)

SUBMITTER: Smith JJ 

PROVIDER: S-EPMC5805609 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature