A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion.

ABSTRACT: Glioblastoma is the most frequent primary brain tumor in adults and a highly lethal malignancy with a median survival of about 15 months. The aggressive invasion of the surrounding normal brain makes complete surgical resection impossible, increases the resistance to radiation and chemotherapy, and assures tumor recurrence. Thus, there is an urgent need to develop innovative therapeutics to target the invasive tumor cells for improved treatment outcomes of this disease. Expression of TROY (TNFRSF19), a member of the tumor necrosis factor (TNF) receptor family, increases with increasing glial tumor grade and inversely correlates with patient survival. Increased expression of TROY stimulates glioblastoma cell invasion in vitro and in vivo and increases resistance to temozolomid

SUBMITTER: Ding Z 

PROVIDER: S-EPMC5805628 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature