The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.

ABSTRACT: Circulating CCR2⁺ monocytes are crucial for maintaining the adult tissue-resident F4/80^hiMHCII^hi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80^hiMHCII^low macrophages, which are the most abundant F4/80^hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80^hi cells. In colon adenomas of Apc^Min/+ mice, F4/80^hiMHCII^low macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, these pro-tumoural F4/80^hiMHCII^low and F4/80^hiMHCII

SUBMITTER: Soncin I 

PROVIDER: S-EPMC5805689 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature