Ontology highlight
ABSTRACT:
SUBMITTER: Stone WJR
PROVIDER: S-EPMC5805765 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180208 1
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based m ...[more]