Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments.

ABSTRACT: Combined radiotherapy and hyperthermia offer great potential for the successful treatment of radio-resistant tumours through thermo-radiosensitization. Tumour response heterogeneity, due to intrinsic, or micro-environmentally induced factors, may greatly influence treatment outcome, but is difficult to account for using traditional treatment planning approaches. Systems oncology simulation, using mathematical models designed to predict tumour growth and treatment response, provides a powerful tool for analysis and optimization of combined treatments. We present a framework that simulates such combination treatments on a cellular level. This multiscale hybrid cellular automaton simulates large cell populations (up to 107 cells) in vitro, while allowing individual cell-cycle progression, and

SUBMITTER: Bruningk S 

PROVIDER: S-EPMC5805969 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature