The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults.

ABSTRACT:

Background

While common variant non-HLA (human leukocyte antigen) alleles have been associated with MS risk, their role in disease course is less clear. We sought to determine whether established multiple sclerosis (MS) genetic susceptibility factors are associated with relapse rate in children and an independent cohort of adults with MS.

Methods

Genotyping was performed for 182 children with MS or clinically isolated syndrome with high risk for MS from two Pediatric MS Centers. They were prospectively followed for relapses. Fifty-two non-HLA MS susceptibility single nucleotide polymorphisms (SNPs) were evaluated for association with relapse rate. Cox regression models were adjusted for sex, genetic ancestry, disease-modifying therapy (DMT), 25-OH vitamin D level and HLA-DRB

SUBMITTER: Graves JS 

PROVIDER: S-EPMC5806144 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature