Possible correlation between gut microbiota and immunity among healthy middle-aged and elderly people in southwest China.

ABSTRACT:

Background

The present study was conducted to investigate the possible association between gut microbes and immunity among healthy middle-aged and elderly individuals in southwest China. A total of 148 healthy adults aged ≥ 50 years were divided into two age groups: middle-aged group (50-59 years; n = 67, 54.13 ± 3.32) and elderly group (≥ 60 years; n = 81, 64.70 ± 3.93). Blood samples were collected to measure serum immune and biochemical indices. Gut microbiota compositions of the groups were characterized on the basis of faecal DNA using 16S rRNA gene sequencing.

Results

Among the detected gut microbes, the presence of Alistipes was negatively correlated with age in both groups. In the middle-aged group, age was negatively correlated with the presence of Desulfo

SUBMITTER: Shen X 

PROVIDER: S-EPMC5806246 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature