Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls.

ABSTRACT:

Background

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has important roles in the periodontal diseases. The IL10-1082, -819, and -592 polymorphisms in the promoter region of IL-10 gene have been associated with various IL-10 expressions. The aim of this study was to investigate the association between these gene polymorphisms with chronic periodontitis in a sample of Iranian populations from Southeast of Iran.

Materials and methods

IL-10 single nucleotide polymorphisms were analyzed in 210 patients with chronic periodontitis (CP) and 100 individuals without CP by polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis of data was performed using the Chi-square test. The risk associated with single alleles, genotypes, a

SUBMITTER: Moudi B 

PROVIDER: S-EPMC5806433 | biostudies-literature | 2018 Jan-Feb

REPOSITORIES: biostudies-literature