Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.

ABSTRACT:

Background

Endothelial cell (EC) regeneration is essential for inflammation resolution and vascular integrity recovery after inflammatory vascular injury. Cdc42 is a central regulator of cell survival and vessel formation in EC development. However, it is unknown that whether Cdc42 could be a regulating role of EC repair following the inflammatory injury in the lung. The study sought to test the hypothesis that Cdc42 is required for endothelial regeneration and vascular integrity recovery after LPS-induced inflammatory injury.

Methods and results

The role of Cdc42 for the regulation of pulmonary vascular endothelial repair was tested in vitro and in vivo. In LPS-induced acute lung injury (ALI) mouse models, knockout of the Cdc42 gene in ECs increased inflammatory cell infilt

SUBMITTER: Lv J 

PROVIDER: S-EPMC5806471 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature