Familial Risk for Insomnia Is Associated With Abnormal Cortisol Response to Stress.

ABSTRACT: Abnormalities in the stress system have been implicated in insomnia. However, studies examining physiological stress regulation in insomnia have not consistently detected differences in the hypothalamic-pituitary-adrenal (HPA)-axis response to stress. One explanation may be that deficits in the stress system are associated specifically with a biological vulnerability to insomnia rather than the phenotypic expression of insomnia. To examine stress response as a function of vulnerability to insomnia, this study tested response to the Trier Social Stress Test in a sample of healthy sleepers with varying familial risks for insomnia. Thirty-five healthy individuals with and without familial risk for insomnia were recruited to complete a laboratory stressor. Participants with one or both biologi

SUBMITTER: Drake CL 

PROVIDER: S-EPMC5806584 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature