Clinical Application of Genetic Testing in Heart Failure.

ABSTRACT:

Purpose of review

The purpose of this review is to present our current understanding of the genetic etiologies that may cause or predispose to heart failure. We highlight known phenotypes for which a genetic evaluation has clinical utility.

Recent findings

The literature continues to demonstrate and confirm a genetic basis for conditions that cause heart failure. Evidence suggests a genetic model involving rare and common variants of strong or weak effect, in combination with environmental factors that may manifest as familial or simplex disease. Clinical genetic testing is available for several phenotypes, which can aid in the diagnosis and identification of at-risk family members. The evaluation of heart failure should include investigating etiologies with a genetic basis.

SUBMITTER: Morales A 

PROVIDER: S-EPMC5806624 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature