ATP is stored in lamellar bodies to activate vesicular P2X₄ in an autocrine fashion upon exocytosis.

ABSTRACT: Vesicular P2X₄ receptors are known to facilitate secretion and activation of pulmonary surfactant in the alveoli of the lungs. P2X₄ receptors are expressed in the membrane of lamellar bodies (LBs), large secretory lysosomes that store lung surfactant in alveolar type II epithelial cells, and become inserted into the plasma membrane after exocytosis. Subsequent activation of P2X₄ receptors by adenosine triphosphate (ATP) results in local fusion-activated cation entry (FACE), facilitating fusion pore dilation, surfactant secretion, and surfactant activation. Despite the importance of ATP in the alveoli, and hence lung function, the origin of ATP in the alveoli is still elusive. In this study, we demonstrate that ATP is stored within LBs themselves at a concen

SUBMITTER: Fois G 

PROVIDER: S-EPMC5806682 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature