Echocardiographic evaluation of diastolic function in mouse models of heart disease.

ABSTRACT:

Background

Mouse models of heart disease are extensively employed. The echocardiographic characterization of contractile function is usually focused on systolic function with fewer studies assessing diastolic function. Furthermore, the applicability of diverse echocardiographic parameters of diastolic function that are commonly used in humans has not been extensively evaluated in different pathophysiological models in mice.

Methods and results

We used high resolution echocardiography to evaluate parameters of diastolic function in mouse models of chronic pressure overload (aortic constriction), volume overload (aorto-caval shunt), heart failure with preserved ejection fraction (HFpEF; DOCA-salt hypertension), and acute sarcoplasmic reticulum dysfunction induced by thapsigarg

SUBMITTER: Schnelle M 

PROVIDER: S-EPMC5807035 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature