Audiologic Natural History of Small Volume Cochleovestibular Schwannomas in Neurofibromatosis Type 2.

ABSTRACT:

Objective

To characterize the audiometric natural progression in patient-ears with small volume (<1,000 mm), treatment-naïve cochleovestibular schwannomas (CVSs) in Neurofibromatosis Type 2 (NF2).

Study design

Prospective, longitudinal cohort study.

Setting

Quaternary medical research institute.

Patients

One hundred eleven ears in 71 NF2 patients with small, treatment-naïve CVSs observed from July 2006 to July 2016.

Intervention

Serial audiometric testing, including pure tone audiometry, speech audiometry, and magnetic resonance imaging (MRI).

Outcome measures

Four-frequency pure tone average (4f-PTA) of 0.5, 1, 2, and 4 kHz and word recognition score (WRS) were recorded. Their changes were compared with MRI changes in CVS volume over time. Times

SUBMITTER: deTorres AT 

PROVIDER: S-EPMC5807117 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature