Differential change on depressive symptom factors with antidepressant medication and cognitive behavior therapy for major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a heterogeneous condition and individual patients are likely to be differentially responsive to specific treatments. In an exploratory factor analysis of three rating scales, the Genome-based Therapeutic Drugs for Depression (GENDEP) trial identified three factors that were differentially associated with outcome to nortriptyline and escitalopram. However, this factor analysis has neither been replicated or applied to a psychotherapy treatment.

Methods

We replicated the GENDEP analytic method in the Emory Predictors of Remission to Individual and Combined Treatments (PReDICT) study. The 17-item Hamilton Depression Rating Scale, Montgomery Asberg Depression Rating Scale, and Beck Depression Inventory were administered to 306 MDD pa

SUBMITTER: Dunlop BW 

PROVIDER: S-EPMC5807140 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature