Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences.

ABSTRACT:

Background and aims

The activity of CYP2A6, the major nicotine-inactivating enzyme, is measurable in smokers using the nicotine metabolite ratio (NMR; 3'hydroxycotinine/cotinine). Due to its role in nicotine clearance, the NMR is associated with smoking behaviours and response to pharmacotherapies. The NMR is highly heritable (~80%), and on average lower in African Americans (AA) versus whites. We previously identified several reduce and loss-of-function CYP2A6 variants common in individuals of African descent. Our current aim was to identify novel genetic influences on the NMR in AA smokers using genome-wide approaches.

Design

Genome-wide association study (GWAS).

Setting

Multiple sites within Canada and the United States.

Participants

AA smokers from two clin

SUBMITTER: Chenoweth MJ 

PROVIDER: S-EPMC5807179 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature