Applications of sequence coevolution in membrane protein biochemistry.

ABSTRACT: Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct methods, which use global statistical models of sequence coevolution, have enabled the prediction of membrane and disordered protein structures, protein complex architectures, and the functional effects of mutations in proteins. The field of membrane protein biochemistry and structural biology has embraced these computational techniques, which provide functional and structural information in an otherwise experimentally-challenging field. Here we review recent applications of protein sequence coevolution analysis to membrane protein structure and function and highlight the promising directions and future obstacles in these fields. We provide insights and guidel

SUBMITTER: Nicoludis JM 

PROVIDER: S-EPMC5807202 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature