Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.

ABSTRACT: Germ-line mutations in breast cancer susceptibility gene, BRCA1, result in familial predisposition to breast and ovarian cancers. The BRCA1 protein has multiple functional domains that interact with a variety of proteins in multiple cellular processes. Understanding the biological consequences of BRCA1 interactions with its binding partners is important for elucidating its tissue-specific tumor suppression function. The Cofactor of BRCA1 (COBRA1) is a BRCA1-binding protein that, as a component of negative elongation factor (NELF), regulates RNA polymerase II pausing during transcription elongation. We recently identified a genetic interaction between mouse Brca1 and Cobra1 that antagonistically regulates mammary gland development. However, it remains unclear which of the myriad functions o

SUBMITTER: Chiang HC 

PROVIDER: S-EPMC5807304 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature