Elavl3 is essential for the maintenance of Purkinje neuron axons.

ABSTRACT: Neuronal Elav-like (nElavl or neuronal Hu) proteins are RNA-binding proteins that regulate RNA stability and alternative splicing, which are associated with axonal and synaptic structures. nElavl proteins promote the differentiation and maturation of neurons via their regulation of RNA. The functions of nElavl in mature neurons are not fully understood, although Elavl3 is highly expressed in the adult brain. Furthermore, possible associations between nElavl genes and several neurodegenerative diseases have been reported. We investigated the relationship between nElavl functions and neuronal degeneration using Elavl3^-/- mice. Elavl3^-/- mice exhibited slowly progressive motor deficits leading to severe cerebellar ataxia, and axons of Elavl3^-/- Purkinje cells

SUBMITTER: Ogawa Y 

PROVIDER: S-EPMC5807307 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature