Genetic Separation of Listeria monocytogenes Causing Central Nervous System Infections in Animals.

ABSTRACT: Listeria monocytogenes is a foodborne pathogen that causes abortion, septicemia, gastroenteritis and central nervous system (CNS) infections in ruminants and humans. L. monocytogenes strains mainly belong to two distinct phylogenetic groups, named lineages I and II. In general, clinical cases in humans and animals, in particular CNS infections, are caused by lineage I strains, while most of the environmental and food strains belong to lineage II. Little is known about why lineage I is more virulent than lineage II, even though various molecular factors and mechanisms associated with pathogenesis are known. In this study, we have used a variety of whole genome sequence analyses and comparative genomic tools in order to find characteristics that distinguish lineage I from linea

SUBMITTER: Aguilar-Bultet L 

PROVIDER: S-EPMC5807335 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature