High Throughput Measurement of Locomotor Sensitization to Volatilized Cocaine in Drosophila melanogaster.

ABSTRACT: Drosophila melanogaster can be used to identify genes with novel functional roles in neuronal plasticity induced by repeated consumption of addictive drugs. Behavioral sensitization is a relatively simple behavioral output of plastic changes that occur in the brain after repeated exposures to drugs of abuse. The development of screening procedures for genes that control behavioral sensitization has stalled due to a lack of high-throughput behavioral tests that can be used in genetically tractable organism, such as Drosophila. We have developed a new behavioral test, FlyBong, which combines delivery of volatilized cocaine (vCOC) to individually housed flies with objective quantification of their locomotor activity. There are two main advantages of FlyBong: it is high-throughput and it allow

SUBMITTER: Filosevic A 

PROVIDER: S-EPMC5807336 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature