Ontology highlight
ABSTRACT:
SUBMITTER: Galonska C
PROVIDER: S-EPMC5807365 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Nature communications 20180209 1
In normal mammalian development cytosine methylation is essential and is directed to specific regions of the genome. Despite notable advances through mapping its genome-wide distribution, studying the direct contribution of DNA methylation to gene and genome regulation has been limited by the lack of tools for its precise manipulation. Thus, combining the targeting capability of the CRISPR-Cas9 system with an epigenetic modifier has attracted interest in the scientific community. In contrast to ...[more]