Galectin-1 is required for the regulatory function of B cells.

ABSTRACT: Galectin-1 (Gal-1) is required for the development of B cells in the bone marrow (BM), however very little is known about the contribution of Gal-1 to the development of B cell regulatory function. Here, we report an important role for Gal-1 in the induction of B cells regulatory function. Mice deficient of Gal-1 (Gal-1^-/-) showed significant loss of Transitional-2 (T2) B cells, previously reported to include IL-10⁺ regulatory B cells. Gal-1^-/- B cells stimulated in vitro via CD40 molecules have impaired IL-10 and Tim-1 expression, the latter reported to be required for IL-10 production in regulatory B cells, and increased TNF-α expression compared to wild type (WT) B cells. Unlike their WT counterparts, T2 and T1 Gal-1^-/- B cells did not suppres

SUBMITTER: Alhabbab R 

PROVIDER: S-EPMC5807431 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature