Proteome-wide comparison between the amino acid composition of domains and linkers.

ABSTRACT:

Objective

Amino acid composition is a sequence feature that has been extensively used to characterize proteomes of many species and protein families. Yet the analysis of amino acid composition of protein domains and the linkers connecting them has received less attention. Here, we perform both a comprehensive full-proteome amino acid composition analysis and a similar analysis focusing on domains and linkers, to uncover domain- or linker-specific differential amino acid usage patterns.

Results

The amino acid composition in the 38 proteomes studied showcase the greater variability found in archaea and bacteria species compared to eukaryotes. When focusing on domains and linkers, we describe the preferential use of polar residues in linkers and hydrophobic residues in domains.

SUBMITTER: Brune D 

PROVIDER: S-EPMC5807739 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature