Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study.

ABSTRACT: BACKGROUND:Alcohol consumption is associated with an increased risk of several cancers. Potential mechanisms include altered oestrogen metabolism. Parent oestrogens metabolise into alternate pathways of oestrogen metabolites that may have variable effects on cancer pathogenesis. We examined associations of alcohol consumption with circulating oestrogen/oestrogen metabolites in postmenopausal women in the Women's Health Initiative (WHI)-Observational Study (OS). METHODS:We conducted a cross-sectional analysis of prediagnosis ovarian/endometrial cancer case-control data within WHI-OS (N=1864). Alcohol consumption was measured by validated food frequency questionnaire. Fasting serum parent oestrogens/oestrogen metabolites were assayed using liquid chromatography tandem mass-spectrometry. Geom

SUBMITTER: Playdon MC 

PROVIDER: S-EPMC5808032 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature