No major role of norepinephrine transporter gene variations in the cardiostimulant effects of MDMA.

ABSTRACT:

Purpose

Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α₁-adrenergic receptors. Genetic variants, such as single-nucleotide polymorphisms (SNPs), of the NET gene (SLC6A2) may explain interindividual differences in the acute stimulant-type responses to MDMA in humans.

Methods

We characterized the effects of common genetic variants of the SLC6A2 gene (rs168924, rs47958, rs1861647, rs2242446, and rs36029) on cardiovascular and subjective stimulation after MDMA administration in 124 healthy subjects in a pool

SUBMITTER: Vizeli P 

PROVIDER: S-EPMC5808057 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature