Additive Dose Response Models: Explicit Formulation and the Loewe Additivity Consistency Condition.

ABSTRACT: High-throughput techniques allow for massive screening of drug combinations. To find combinations that exhibit an interaction effect, one filters for promising compound combinations by comparing to a response without interaction. A common principle for no interaction is Loewe Additivity which is based on the assumption that no compound interacts with itself and that two doses from different compounds having the same effect are equivalent. It then should not matter whether a component is replaced by the other or vice versa. We call this assumption the Loewe Additivity Consistency Condition (LACC). We derive explicit and implicit null reference models from the Loewe Additivity principle that are equivalent when the LACC holds. Of these two formulations, the implicit formulation is the known

SUBMITTER: Lederer S 

PROVIDER: S-EPMC5808155 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature