Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture.

ABSTRACT: Influenza virus infections pose a significant threat to public health due to annual seasonal epidemics and occasional pandemics. Influenza is also associated with significant economic losses in animal production. The most effective way to prevent influenza infections is through vaccination. Current vaccine programs rely heavily on the vaccine's ability to stimulate neutralizing antibody responses to the hemagglutinin (HA) protein. One of the biggest challenges to an effective vaccination program lies on the fact that influenza viruses are ever-changing, leading to antigenic drift that results in escape from earlier immune responses. Efforts toward overcoming these challenges aim at improving the strength and/or breadth of the immune response. Novel vaccine technologies, the so-called unive

SUBMITTER: Rajao DS 

PROVIDER: S-EPMC5808216 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature