Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia.

ABSTRACT: Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel physiology was focusing on its fundamental meaning in sensory neuronal function. Today, it is known that activation of several TRP ion channels in peptidergic neurons does not only result in neuropeptide release and consecutive neurogenic inflammation. Growing evidence demonstrates functional extra-neuronal TRP channel expression in immune and epithelial cells with important implications for mucosal immunology. TRP channels maintain intracellular calcium homeostasis to regulate various functions in the respective cells such as nociception, production and release of inflammatory mediators, phagocytosis, and cell migration. In this review, we prov

SUBMITTER: Khalil M 

PROVIDER: S-EPMC5808302 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature