CCR6⁺ Th cell distribution differentiates systemic lupus erythematosus patients based on anti-dsDNA antibody status.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE) disease has been shown to be associated with the generation of multiple auto-antibodies. Among these, anti-dsDNA antibodies (anti-DNAs) are specific and play a pathogenic role in SLE. Indeed, anti-DNA⁺ SLE patients display a worse disease course. The generation of these pathogenic anti-DNAs has been attributed to the interaction between aberrant T helper (Th) cells and autoimmune B cells. Thus, in this study we have investigated whether CCR6⁺Th cells have the ability to differentiate SLE patients based on anti-DNA status, and if their distribution has any correlation with disease activity.

Methods

We recruited 25 anti-DNA⁺ and 25 anti-DNA^- treatment-naive onset SLE patients, matched for

SUBMITTER: Zhong W 

PROVIDER: S-EPMC5808313 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature