Altered functional connectivity to stressful stimuli in prenatally cocaine-exposed adolescents.

ABSTRACT:

Background

Prenatal cocaine exposure (PCE) is linked to addiction and obesity vulnerability. Neural responses to stressful and appetitive cues in adolescents with PCE versus those without have been differentially linked to substance-use initiation. However, no prior studies have assessed cue-reactivity responses among PCE adolescents using a connectivity-based approach.

Methods

Twenty-two PCE and 22 non-prenatally drug-exposed (NDE) age-, sex-, IQ- and BMI-matched adolescents participated in individualized guided imagery with appetitive (favorite-food), stressful and neutral-relaxing cue scripts during functional magnetic resonance imaging. Subjective favorite-food craving scores were collected before and after script exposure. A data-driven voxel-wise intrinsic connectivity

SUBMITTER: Zakiniaeiz Y 

PROVIDER: S-EPMC5808433 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature