OTX1 regulates cell cycle progression of neural progenitors in the developing cerebral cortex.

ABSTRACT: The progenitor cells in the cerebral cortex coordinate proliferation and mitotic exit to generate the correct number of neurons and glial cells during development. However, mechanisms for regulating the mitotic cycle of cortical progenitors are not fully understood. Otx1 is one of the homeobox-containing transcription factors frequently implicated in the development of the central nervous system. Mice bearing a targeted deletion of Otx1 exhibit brain hypoplasia and a decrease in the number of cortical neurons. We hypothesized that Otx1 might be crucial to the proliferation and differentiation of cortical progenitors. Otx1 knockdown by in utero electroporation in the mouse brain reduced the proportion of the G₁ phase while increasing the S and M

SUBMITTER: Huang B 

PROVIDER: S-EPMC5808773 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature