Better diagnostic accuracy of neuropathy in obesity: A new challenge for neurologists.

ABSTRACT: OBJECTIVE:To determine the comparative diagnostic characteristics of neuropathy measures in an obese population. METHODS:We recruited obese participants from the University of Michigan's Weight Management Program. Receiver operative characteristic analysis determined the area under the curve (AUC) of neuropathy measures for distal symmetric polyneuropathy (DSP), small fiber neuropathy (SFN), and cardiovascular autonomic neuropathy (CAN). The best test combinations were determined using stepwise and Score subset selection models. RESULTS:We enrolled 120 obese participants. For DSP, seven of 42 neuropathy measures (Utah Early Neuropathy Score (UENS, N = 62), Michigan Neuropathy Screening Instrument (MNSI) reduced combined index, MNSI examination, nerve fiber density (NFD) leg, tibial F respo

SUBMITTER: Callaghan BC 

PROVIDER: S-EPMC5808853 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature