Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial.

ABSTRACT:

Importance

Stroke is a major complication of surgical aortic valve replacement (SAVR).

Objective

To determine the efficacy and adverse effects of cerebral embolic protection devices in reducing ischemic central nervous system (CNS) injury during SAVR.

Design, setting, and participants

A randomized clinical trial of patients with calcific aortic stenosis undergoing SAVR at 18 North American centers between March 2015 and July 2016. The end of follow-up was December 2016.

Interventions

Use of 1 of 2 cerebral embolic protection devices (n = 118 for suction-based extraction and n = 133 for intra-aortic filtration device) vs a standard aortic cannula (control; n = 132) at the time of SAVR.

Main outcomes and measures

The primary end point was freedom from clin

SUBMITTER: Mack MJ 

PROVIDER: S-EPMC5808875 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature