Higher serum vitamin D levels are associated with protective serum cytokine profiles in patients with ulcerative colitis.

ABSTRACT: BACKGROUND & AIMS:Vitamin D has immune modulating effects on cytokines. Serum vitamin D levels are associated with the risk of relapse in patients with ulcerative colitis (UC), through unknown mechanisms. We tested the hypothesis that this beneficial role of vitamin D on UC is mediated through anti-inflammatory serum cytokine profiles. METHODS:Serum samples from a prospective cohort of seventy UC patients in clinical remission were collected and baseline histological and endoscopic scores were recorded at enrollment. Clinical relapse events were recorded over the 12-month follow-up period. Serum vitamin D and cytokines levels (IL-6, IL-8, IL-17A, TNF-α, IFN-γ, IL-4, IL-10) were quantified using ELISA. Linear regression was used to determine correlation between vitamin D and cytokine profil

SUBMITTER: Gubatan J 

PROVIDER: S-EPMC5808893 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature