Inflammatory response to mental stress and mental stress induced myocardial ischemia.

ABSTRACT:

Background

Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia.

Methods

Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor. MSIMI was determined as impaired myocardial perfusion using a 17-segment model. Inflammatory markers including interleukin-6 (IL-6), monocyte chemoattractan

SUBMITTER: Hammadah M 

PROVIDER: S-EPMC5808921 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature