Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.

ABSTRACT: Experimental monoclonal antibody (mAb) therapies have shown promise for treatment of lethal Ebola virus (EBOV) infections, but their species-specific recognition of the viral glycoprotein (GP) has limited their use against other divergent ebolaviruses associated with human disease. Here, we mined the human immune response to natural EBOV infection and identified mAbs with exceptionally potent pan-ebolavirus neutralizing activity and protective efficacy against three virulent ebolaviruses. These mAbs recognize an inter-protomer epitope in the GP fusion loop, a critical and conserved element of the viral membrane fusion machinery, and neutralize viral entry by targeting a proteolytically primed, fusion-competent GP intermediate (GP_CL) generated in host cell endosomes. Only a few s

SUBMITTER: Wec AZ 

PROVIDER: S-EPMC5808922 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature