Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.

ABSTRACT: Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. However, the personalized identification and validation of neoantigens remains a major challenge. Here we discover neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and class II molecules. We applied this approach to systematically characterize MHC ligands from 17 patients. Remarkably, all discovered neoantigenic peptides were exclusively derived from the lymphoma immunoglobulin heavy- or light-chain variable regions. Although we identified MHC presentation of private polymorphic germline alleles, no mutated peptides were recovered from non-immunogl

SUBMITTER: Khodadoust MS 

PROVIDER: S-EPMC5808925 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature