Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function.

ABSTRACT: The incidence of high blood pressure with advancing age is notably high, and it is an independent prognostic factor for the onset or progression of a variety of cardiovascular disorders. Although age-related hypertension is an established phenomenon, current treatments are only palliative but not curative. Thus, there is a critical need for a curative therapy against age-related hypertension, which could greatly decrease the incidence of cardiovascular disorders. We show that overexpression of human thioredoxin (TRX), a redox protein, in mice prevents age-related hypertension. Further, injection of recombinant human TRX (rhTRX) for three consecutive days reversed hypertension in aged wild-type mice, and this effect lasted for at least 20 days. Arteries of wild-type mice injected with rhTRX

SUBMITTER: Hilgers RH 

PROVIDER: S-EPMC5808940 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature