Inferring sex-specific demographic history from SNP data.

ABSTRACT: The relative female and male contributions to demography are of great importance to better understand the history and dynamics of populations. While earlier studies relied on uniparental markers to investigate sex-specific questions, the increasing amount of sequence data now enables us to take advantage of tens to hundreds of thousands of independent loci from autosomes and the X chromosome. Here, we develop a novel method to estimate effective sex ratios or ESR (defined as the female proportion of the effective population) from allele count data for each branch of a rooted tree topology that summarizes the history of the populations of interest. Our method relies on Kimura's time-dependent diffusion approximation for genetic drift, and is based on a hierarchical Bayesian model to integra

SUBMITTER: Clemente F 

PROVIDER: S-EPMC5809101 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature