Macrogenomic engineering via modulation of the scaling of chromatin packing density.

ABSTRACT: Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through the combination of simulations, systems modelling and in vitro experiments, we provide a physical regulatory framework based on chromatin packing-density heterogeneity for modulating the genomic information space. Because transcriptional interactions are essentially chemical reactions, they depend largely on the local physical nanoenvironment. We show that the regulation of the chromatin nanoenvironment allows for the predictable modulation of global patterns in gene expression. In particular, we show that the rational modulation of chromatin den

SUBMITTER: Almassalha LM 

PROVIDER: S-EPMC5809134 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature