APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease.

ABSTRACT: BACKGROUND:People with PD are at high risk of developing cognitive impairment and dementia. Cross-sectional studies have identified candidate biomarkers associated with cognitive decline. However, longitudinal studies on this topic are rarer, and few have investigated the use of biomarker panels encompassing multiple modalities. The objective of this study was to find baseline predictors of cognitive decline in longitudinally followed, nondemented Parkinson's disease patients. METHODS:We performed a prospective cohort study of 100 PD patients with a median disease duration of 6.4 years. All participants were nondemented at baseline. We examined 16 baseline biomarkers from clinical, genetic, biochemical, and MRI-based imaging modalities for their association with longitudinal cognitive decl

SUBMITTER: Tropea TF 

PROVIDER: S-EPMC5809205 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature