Meta-analysis of Interventions to Reduce Adverse Drug Reactions in Older Adults.

ABSTRACT: OBJECTIVES:To examine the effect of interventions to optimize medication use on adverse drug reactions (ADRs) in older adults. DESIGN:Systematic review and meta-analysis. EMBASE, PubMed, OVID, Cochrane Library, Clinicaltrials.gov, and Google Scholar were searched through April 30, 2017. SETTING:Randomized controlled trials. PARTICIPANTS:Older adults (mean age ≥65) taking medications. MEASUREMENTS:Two authors independently extracted relevant information and assessed studies for risk of bias. Discrepancies were resolved in consensus meetings. The outcomes were any and serious ADRs. Random-effects models were used to combine the results of multiple studies and create summary estimates. RESULTS:Thirteen randomized controlled trials involving 6,198 older adults were included. The studies employ

SUBMITTER: Gray SL 

PROVIDER: S-EPMC5809283 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature