Mature Hippocampal Neurons Require LIS1 for Synaptic Integrity: Implications for Cognition.

ABSTRACT:

Background

Platelet-activating factor acetylhydrolase 1B1 (LIS1), a critical mediator of neuronal migration in developing brain, is expressed throughout life. However, relatively little is known about LIS1 function in the mature brain. We previously demonstrated that LIS1 involvement in the formation and turnover of synaptic protrusions and synapses of young brain after neuronal migration is complete. Here we examine the requirement for LIS1 to maintain hippocampal circuit function in adulthood.

Methods

Effects of conditional Lis1 inactivation in excitatory pyramidal neurons, starting in juvenile mouse brain, were probed using high-resolution approaches combining mouse genetics, designer receptor exclusively activated by designer drug technology to specifically manipulate CA

SUBMITTER: Sudarov A 

PROVIDER: S-EPMC5809292 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature