Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.

ABSTRACT:

Background

Many sepsis survivors develop chronic critical illness (CCI) and are assumed to be immunosuppressed, but there is limited clinical evidence to support this. We sought to determine whether the incidence of secondary infections and immunosuppressive biomarker profiles of patients with CCI differ from those with rapid recovery (RAP) after sepsis.

Methods

This prospective observational study evaluated 88 critically ill patients with sepsis and 20 healthy controls. Cohorts were defined based on clinical trajectory (early death, RAP, or CCI), whereas immunosuppression was clinically determined by the presence of a postsepsis secondary infection. Serial blood samples were collected for absolute lymphocyte counts (ALCs), monocytic human leukocyte antigen-DR (mHLA-DR) expr

SUBMITTER: Stortz JA 

PROVIDER: S-EPMC5809297 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature