Microvesicle-mediated delivery of miR-1343: impact on markers of fibrosis.

ABSTRACT: Tissue fibrosis, the development of fibrous connective tissue as a result of injury or damage, is associated with many common diseases and cannot be treated effectively. The complex biological processes accompanying fibrosis often involve aberrant signaling through the transforming growth factor beta (TGF-β) pathway. In the search for mechanisms to repress this signaling, microRNAs have emerged as a novel class of molecules capable of targeting single members of the TGF-β pathway, or the pathway as a whole. We previously identified miR-1343 as a potent repressor of TGF-β signaling and fibrosis through the direct attenuation of both canonical TGF-β receptors. Here, we build upon our previous findings to better characterize the function of endogenous miR-1343 in normal biology and examine th

SUBMITTER: Stolzenburg LR 

PROVIDER: S-EPMC5809304 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature