Proton Pump Inhibitor Use and Dementia Risk: Prospective Population-Based Study.

ABSTRACT:

Objectives

To determine whether higher cumulative proton pump inhibitor (PPI) exposure is associated with greater dementia risk.

Design

Prospective population-based cohort study.

Setting

Kaiser Permanente Washington, an integrated healthcare delivery system in Seattle, Washington.

Participants

Individuals aged 65 and older without dementia at study entry (N = 3,484).

Measurements

Participants were screened for dementia every 2 years, and those who screened positive underwent extensive evaluation. Dementia outcomes were determined using standard diagnostic criteria. Time-varying PPI exposure was determined from computerized pharmacy data and consisted of total standardized daily doses (TSDDs) dispensed to an individual in the prior 10 years. We also asses

SUBMITTER: Gray SL 

PROVIDER: S-EPMC5809315 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature