Growth factors for diabetic foot ulcers: mixed treatment comparison analysis of randomized clinical trials.

ABSTRACT:

Aims

Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head-to-head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors.

Methods

Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Proportion of patients with complete healing was the primary outcome. Odds ratio (95% confidence interval) was used as the effect estimate and random effects model was used for both direct and indirect comparisons. Markov Chain Monte Carlo simulation was used to obtain pooled estimates. Rankogram was generated based on surface under the cumulative ranking curve (SUCRA

SUBMITTER: Sridharan K 

PROVIDER: S-EPMC5809344 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature